Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
Volume 89B, Issue 2, Pages 558-574Publisher
WILEY
DOI: 10.1002/jbm.b.31220
Keywords
bone cement-PMMA; acrylic; antimicrobial; mechanical properties
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Infection of periprosthetic sites of total joint replacements has been widely reported. Although, by most accounts, the incidence of such events is low, the problem can prove to be expensive to remedy. In the case of cemented arthroplasties, a common management modality is the use of anti biotic-loaded acrylic bone cement (ALABC) as a prophylaxis or a therapeutic agent. Although there is a large literature on properties of ALABCs (on the order of 100 journal articles), a comprehensive review is lacking. The present contribution, whose objective is to rill this gap, is organized in four parts. Details of the background to and motivation for the work are given in the first part, explicative summaries of literature studies on the influence of various factors on an array of in vitro and in vivo properties of ALABCs are covered in the second part, issues and areas for future studies are presented in the third part, and the fourth part contains a summary of the most salient points made in the review. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 89B: 558574,2009
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