Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 103, Issue 8, Pages 2540-2548Publisher
WILEY
DOI: 10.1002/jbm.a.35390
Keywords
ferroelectric; lithium niobate; polarization; surface charge; inorganic ions; MC3T3; biocompatible
Funding
- Science Foundation Ireland [SFI13/CW/B2538, SFI07/IN1/B931]
- Swedish Research Council [VR 622-2010-526, 621-2011-4040]
- Programme for Research in Third-Level Institutions cycle 5 (PRTLI-5)
- European Regional Development Fund [DGPP, NANOREMEDIES]
- ADOPT Linnaeus Centre for Advanced Optics and Photonics in Stockholm
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In this work, the influence of substrate surface charge on in vitro osteoblast cell proliferation on ferroelectric lithium niobate (LN) crystal surfaces is investigated. LN has a spontaneous polarization along the z-axis and is thus characterized by positive and negative bound polarization charge at the +z and -z surfaces. Biocompatibility of LN was demonstrated via culturing and fluorescence imaging of MC3T3 osteoblast cells for up to 11 days. The cells showed enhanced proliferation rates and improved osteoblast function through mineral formation on the positively and negatively charged LN surfaces compared to electrostatically neutral x-cut LN and a glass cover slip control. These results highlight the potential of LN as a template for investigating the role of charge on cellular processes. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2540-2548, 2015.
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