Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 102, Issue 9, Pages 3140-3153Publisher
WILEY
DOI: 10.1002/jbm.a.34985
Keywords
strontium-substituted bioactive glass; polycaprolactone; melt electrospinning; bioactive scaffolds; bone tissue engineering
Funding
- Australian Research Council Linkage [LP110200082]
- Australian Research Council [LP100200084]
- Australian Research Council [LP100200084, LP110200082] Funding Source: Australian Research Council
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Polycaprolactone (PCL) is a resorbable polymer used extensively in bone tissue engineering owing to good structural properties and processability. Strontium-substituted bioactive glass (SrBG) has the ability to promote osteogenesis and may be incorporated into scaffolds intended for bone repair. Here, we describe for the first time, the development of a PCL-SrBG composite scaffold incorporating 10% (weight) of SrBG particles into PCL bulk, produced by the technique of melt electrospinning. We show that we are able to reproducibly manufacture composite scaffolds with an interconnected porous structure and, furthermore, these scaffolds were demonstrated to be noncytotoxic in vitro. Ions present in the SrBG component were shown to dissolve into cell culture media and promoted precipitation of a calcium phosphate layer on the scaffold surface which in turn led to noticeably enhanced alkaline phosphatase activity in MC3T3-E1 cells compared to PLC-only scaffolds. These results suggest that melt-electrospun PCL-SrBG composite scaffolds show potential to become effective bone graft substitutes. (C) 2013 Wiley Periodicals, Inc.
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