Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 101, Issue 8, Pages 2436-2447Publisher
WILEY
DOI: 10.1002/jbm.a.34521
Keywords
injectable; bone regeneration; biocompatibility; gel; polymer; microspheres; biodegradation; stem cells
Funding
- National Science Foundation [0652024]
- National Institute of Health [DE019508]
- University of Toledo
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0652024] Funding Source: National Science Foundation
Ask authors/readers for more resources
This article reviews the potential injectable polymeric biomaterial scaffolds currently being investigated for application in bone tissue regeneration. Two types of injectable biomaterial scaffolds are focused in this review, including injectable microspheres and injectable gels. The injectable microspheres section covers several polymeric materials, including poly(L-lactide-co-glycolide)-PLGA, poly(propylene fumarate), and chitosan. The injectable gel section covers alginate gels, hyaluronan hydrogels, poly(ethylene-glycol)-PEG hydrogels, and PEG-PLGA copolymer hydrogels. This review focuses on the effect of cellular behavior in vitro and in vivo in terms of material properties of polymers, such as biodegradation, biocompatibility, porosity, microsphere size, and cross-linking nature. Injectable polymeric biomaterials offer a major advantage for orthopedic applications by allowing the ability to use noninvasive or minimally invasive treatment methods. Therefore, combining injectable polymeric biomaterial scaffolds with cells have a significant potential to treat orthopedic bone defects, including spine fusion, and craniofacial and periodontal defects. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available