Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 102, Issue 1, Pages 49-59Publisher
WILEY
DOI: 10.1002/jbm.a.34678
Keywords
integrin avb3; aptamer; angiogenesis; magnetic nanoparticle; magnetic resonance imaging
Funding
- National Research Foundation of Korea (NRF), Ministry of Education Science Technology [2012-2043991]
- National R&D Program for Cancer Control, Ministry for Health and Welfare [1020340]
- Bio & Medical Technology Development Program of the National Research Foundation (NRF)
- Korean government (MEST), Republic of Korea [2012050077]
- KRCF Research Initiative Program
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An understanding of neovascularization and/or angiogenesis in cancer is acutely required for effective cancer therapy due to concerns about tumor growth and metastasis. In particular, integrin v3 is closely associated with cell migration and invasion during angiogenesis. Hence, we developed aptamer(v3)-conjugated magnetic nanoparticles (Apt(v3)-MNPs) to enable precise detection of integrin-expressing cancer cells using magnetic resonance imaging. Apt(v3)-MNPs exhibited not only cytocompatibility, but also an efficient targeting ability with high magnetic sensitivity through in vitro/in vivo studies. The results of this study demonstrate that Apt(v3)-MNPs have the potential to be used for accurate tumor diagnosis and therapy. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 49-59, 2014.
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