Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 101, Issue 7, Pages 1898-1906Publisher
WILEY
DOI: 10.1002/jbm.a.34494
Keywords
metallic implant; mechanical properties; degradation properties; anti-inflammatory activity
Funding
- National Natural Science Foundation of China [51101142, 50821001]
- Postdoctoral Science Foundation [2012M510766]
- Science Foundation for the Excellent Youth Scholars of Hebei Province [Y2012019]
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The objective of this study was to prepare a new biodegradable Mg-based biomaterial, which provides good mechanical integrity in combination with anti-inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti-inflammatory core. The new degradable Mg-Zn-Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening. In addition, the alloys exhibited good cytocompatibility. The anti-inflammatory function of degradation products was identified by both interleukin-1 and nitric oxide modes. The anti-inflammatory impact was significantly associated with the concentration of silver ion. It was demonstrated that Mg-Zn-Ag system was a potential metallic stent with anti-inflammatory function, which can reduce the long-term dependence of anti-inflammatory drug after coronary stent implantation. (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.
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