Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 100A, Issue 11, Pages 2881-2889Publisher
WILEY
DOI: 10.1002/jbm.a.34223
Keywords
biodegradation; iron; implant material; coil; mouse model
Funding
- German Research Foundation - Collaborative Research Centre 599
- HEC-DAAD
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A small animal model was established to evaluate the potential of iron as a degradable implant material. After insertion into the tail of mice, the implants gradually degraded over a clinically relevant time period of several months. Histological analysis and gene expression data from whole-genome microarray analyses indicated a limited inflammatory reaction. No evidence of cellular responses to excess iron ions was detected, suggesting that the iron degradation products were metabolically inactive. Iron-rich compounds could be detected in the vicinity of the implant and in individual cells distant from the implantation site. These results demonstrate that the mouse model could be useful for the primary in vivo evaluation of novel implant materials and that iron degradation products can accumulate in diverse organs of the body. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A:28812889, 2012.
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