Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 100A, Issue 5, Pages 1307-1315Publisher
WILEY
DOI: 10.1002/jbm.a.34056
Keywords
PEG hydrogel; aerogel; photopolymerization; supercritical CO2; ketoprofen
Funding
- College of Engineering at Koc University in Turkey, TUBITAK [107M326]
- Marie Curie FP7-IRG [239471]
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A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.
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