Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 100A, Issue 7, Pages 1839-1845Publisher
WILEY
DOI: 10.1002/jbm.a.34142
Keywords
electrospinning; nanofibers; thermoresponsive; PNIPAAm; PAMPS; drug release
Funding
- Program for New Century Excellent Talents in University of China [NCET-08-0165]
- National Natural Science Foundation of China [50675045]
Ask authors/readers for more resources
Electrospinning micro- and nanofibers are being increasingly investigated for drug delivery. The components and their stimuli-responsive properties of fibers are important factors influencing the drug release behavior. The aim of this study is to fabricate thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm)/poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) nanofibers by single-spinneret electrospinning technique. The electrospun nanofibers are used as a drug carrier by cospinning with nifedipine (NIF), and the release behaviors of NIF from the thermoresponsive nanofibers can be controlled by the response of nanofibers with temperature. The morphology of the nanofibers and its composites with NIF was determined by scanning electron microscopy (SEM). The hydrogen bond interactions between PNIPAAm/PAMPS and the water-insoluble drug of NIF were introduced and confirmed by Fourier-transform infrared spectroscopy and energy dispersive spectrometer. The thermoresponsive properties of nanofibers were investigated by contact angle (CA) measurements. The release behaviors of NIF from the PNIPAAm/PAMPS nanofibers were observed by SEM and demonstrated by UVvis spectroscopy. It was found that uniform fibers of NIF and PNIPAAm/PAMPS could be fabricated without particles on the surface. The release of NIF from nanofibers could be controlled effectively by the changes of hydrogen bonds between PNIPAAm/PAMPS and NIF, and by adjusting temperatures of the thermoresponsive nanofibers. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available