Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 100A, Issue 7, Pages 1868-1876Publisher
WILEY-BLACKWELL
DOI: 10.1002/jbm.a.34154
Keywords
biomaterials; anticoagulation; interface; dielectric spectroscopy
Funding
- National Natural Science Foundation of China [21074056]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [2008103TSJ0191]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Ask authors/readers for more resources
Polyurethane with zwitterionic phosphorylcholine on the main chain was synthesized and the structures were defined with FTIR and 1HNMR. The mechanical (tensile strength, elastic modulus) and biological (platelet adhesion) evaluations of its blend films with polyurethane were of satisfactory results, which were in accordance with the requirements of the medical devices, showing their potential applications as anticoagulant biomaterials. The dielectric spectroscopy was recorded with solid films and with films in water. The dielectric dispersion of the solid films demonstrated the existence of condensed ionic structures, which lead to the rigidity enhancement of the soft segment of the phosphorylcholine-based polyurethane, so that its elastic modulus increased. The dielectric measurement with films in water, providing a measurement for the surface properties in the aqueous environment, offered a semiquantitative description of the interface dynamics of the material with a double-layer model, based on which a new hypothesis on the mechanism of blood or bio-compatibility was proposed that the hydrated surface of the satisfactory biomaterials can response to the outside electromagnetic stimuli with slight strength and prompt relaxation. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available