Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 98A, Issue 4, Pages 554-566Publisher
WILEY
DOI: 10.1002/jbm.a.33148
Keywords
bacterial cellulose; RGD; cellulose-binding module; blood compatibility; vascular grafts
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil)
- Programa Operacional Factores de Competitividade (COMPETE)
- Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) [PTDC/EDB/EBI/112170/2009]
- Fundação para a Ciência e a Tecnologia [PTDC/EBB-EBI/112170/2009] Funding Source: FCT
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Among the strategies to improve a material's hemocompatibility, pre-coating with the tripeptide Arg-Gly-Asp (RGD) is used to favor endothelialization thus lowering thrombogenicity. The blood compatibility of native and RGD-modified bacterial cellulose (BC) was studied in this work for the first time. The plasma recalcification time and whole blood clotting results demonstrate the hemocompatibility of BC. A significant amount of plasma protein adsorb to BC fibres, however, according to analysis by intrinsic tryptophan fluorescence techniques when albumin, gamma-globulin, and fibrinogen from pure protein solutions adsorb to BC do not undergo detectable conformational modifications. Human microvascular endothelial cells cultured on RGD-modified BC readily form a confluent cell layer, inhibiting the adhesion of platelets. As a general conclusion, both native and RGD-modified BCs may be classified as hemocompatible materials. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 98A: 554-566, 2011.
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