Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 31, Issue 7, Pages 1062-1069Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfv317
Keywords
acute kidney disease; mitochondrial biogenesis; mitochondrial fusion and fission; mitophagy; tubular damage
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Funding
- Japan Society for the Promotion of Science [25461207, 15KT0088]
- Yakult Bio-Science Foundation
- Kyowa Hakko Kirin Co., Ltd.
- Grants-in-Aid for Scientific Research [15KT0088, 25461207] Funding Source: KAKEN
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Acute kidney injury (AKI) is a common clinical entity that is associated with high mortality and morbidity. It is a risk factor for the development and progression of chronic kidney disease. Presently, no effective treatment for AKI is available, and novel therapeutic approaches are desperately needed. Accumulating evidence highlights mitochondrial dysfunction as an important factor in the pathogenesis of AKI. Recent advances in our understanding of the molecules involved in mitochondrial biogenesis, fusion/fission, mitophagy and their pathophysiological roles will lead to the development of drugs that target mitochondria for the treatment of various diseases, including AKI. In this review, we summarize current knowledge of the contribution of mitochondria-related pathophysiology in AKI and the prospective benefits of mitochondria-targeting therapeutic approaches against AKI.
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