Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 90A, Issue 2, Pages 333-338Publisher
WILEY
DOI: 10.1002/jbm.a.31923
Keywords
mesoporous materials; nanospheres; transfection; DNA; cell
Funding
- Natural Science Foundation of China [20571081, 20633090]
- National Fundament Research Project [2002CB613305]
- Natural Science Foundation of Shanghai [06ZR14163]
- Foundation of Shanghai nanotechnology [0652nm014]
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Mesoporous silica nanospheres (MPNSs) were synthesized by the sol-gel method and were investigated by X-ray diffraction, nitrogen sorption, and transmission electron microscopy. The analyses showed that the MPNSs were highly dispersed, with a diameter range of 50-250 nm. Further, the polycation poly(allylamine hydrochloride) was coated on silica MPNSs to form a positively charged surface and to facilitate the loading of DNA molecules. The composite was Successfully used as a intercellular carrier of DNA molecules, and this was confirmed by agarose get electrophoresis and confocal laser scanning microscopy. Evidently, this composite has potential to be used as a carrier for a DNA delivery system. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A: 333-338, 2009
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