Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 89A, Issue 4, Pages 960-967Publisher
WILEY
DOI: 10.1002/jbm.a.32040
Keywords
antimicrobial; rechargeable; chitosan; biofilm-controlling
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Chitosan, a natural cationic polymer, strongly binds anionic antibiotics (e.g., rifampin) through the formation of ionic complexes. The new system shows sustained rifampin release, leading to potent antimicrobial and biofilm-controlling functions against gram-positive bacteria including Staphylococcus epidermidis and Staphylococcus aureus, which are responsible for a wide range of medical device-related infections, for longer than 30 days. Moreover, the released drugs can be recharged to further extend antimicrobial durations. Drug release mechanisms and potential applications of the new system are also discussed. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 960-967, 2009
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