Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 93A, Issue 2, Pages 595-606Publisher
WILEY
DOI: 10.1002/jbm.a.32565
Keywords
silk fibroin; poly(ethylene glycol); surface modification; cell; antiadhesion; antithrombosis
Funding
- NIH NIBIB
- AFOSR
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Silk fibroin film surfaces were PEGylated by reaction with cyanuric chloride-activated poly(ethylene glycol) (PEG). Reactions with different concentrations of activated PEG generated films with PEG graft densities from 0.02 to 0.4 mg per square cm of silk fibroin. Increased PEGylation resulted in increased hydrophilicity as analyzed by contact angle, and a smoother morphology based on scanning electron microscopy. Increased PEGylation decreased human IgG adsorption and decreased the attachment and proliferation of human fibroblasts over two weeks. Increased concentration of PEG on the silk fibroin surfaces also decreased the proliferation of human mesenchymal stem cells and inhibited human platelet attachment. Surface PEGylated silk fibroin films could be useful antiadhesion and antithrombotic materials for biomedical applications when considered along with the unique mechanical and tailorable degradation profiles of silk fibroin. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 93A: 595-606, 2010
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