Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 84A, Issue 1, Pages 148-157Publisher
WILEY
DOI: 10.1002/jbm.a.31466
Keywords
temperature-sensitive polymer; degradable polymer; poly(ethylene glycol); di(meth)acrylates; Michael addition reaction
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Thermoresponsive polymers have many biomedical applications, but their nondegradability limits their in vivo applications. Herein, we report a new type of degradable thermoresponsive polymers-degradable poly (ethylene glycol) analogues (DPEGs) having lower critical solution temperatures (LCSTs) ranging 10-50 degrees C. DPEGs were synthesized by condensation polymerization of PEG-di(meth)acrylates (PEGDA or PEGDMA) with dithiols. Their LCSTs could be easily tuned by the PEG-chain length and the types of the double bond in the PEG monomers and dithiols. Long PEG chain and the presence of hydrophilic groups in the dithiol monomer increased the LCST of the resulting DPEG. Crosslinking DPEG chains produced thermoresponsive hydrogels. The hydrogels prepared by the end-capping method maintained the thermoresponsive properties of the linear DPEG. The degradable thermoresponsive DPEGs and their hydrogels have great potentials for in vivo biomedical applications. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res 84A: 148-157,2008.
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