Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 85A, Issue 3, Pages 787-796Publisher
WILEY
DOI: 10.1002/jbm.a.31608
Keywords
Au-Au2S nanoparticles; near-IR sensitive; cisplatin; drug delivery; cytotoxicity; in vitro carcinogenicity; cellular uptake
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Cisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin-loaded Au-Au2S nanoparticles (NPs) with near-IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au-Au2S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl4) using sodium sulfide (Na2S), and cisplatin was loaded onto Au-Au2S NPs via a MUA (11-mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin-loaded Au-Au2S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long-term potential carcinogenicity in vitro. Cisplatin-loaded Au-Au2S NPs were also tested for limited hemocompatibility in vitro. Our in vitro short and long-term data provided preliminary evidence suggesting that cisplatin-loaded Au-Au2S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage. (c) 2007 Wiley Periodicals, Inc.
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