Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 89A, Issue 1, Pages 168-175Publisher
WILEY
DOI: 10.1002/jbm.a.31907
Keywords
electrospinning; platelet adhesion; biocompatibility; nanofiber; membrane surface
Funding
- National Natural Science Foundation of China [50625309]
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Fibrous membranes (nonwoven meshes) prepared via electrospinning technique have great potential in tissue engineering. This work is the first study on the behaviors of blood platelets at the nanostructured surface generated by electrospinning. Poly[acrylonitrile-co-(N-vinyl-2-pyrrolidone)] (PANCNVP) that shows excellent antiplatelet adhesion ability was directly electrospun onto its dense membrane surface. Polyacrylonitrile (PAN) samples were used as controls. The depth as well as the density of the nanofibers can be easily controlled. The results showed that the PANCNVP dense membrane certainly suppressed the activation and adhesion of platelets. However, whether the nanofibers and underlying membranes were composed of PAN or PANCNVP, the nanostructured surfaces promoted the activation, adhesion, and orientation of platelets. It was also found that, if the space between fibers was too large or the depth of fibers was too small, the nanostructured surface did not change the property of antiplatelet adhesion of PANCNVP. The promotion of activation and adhesion of platelets was obviously due to the presence of nanofibers, which induced the changes of surface topography and charge. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 168-175, 2009
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