Journal
JOURNAL OF BIOMECHANICS
Volume 47, Issue 2, Pages 451-457Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2013.10.052
Keywords
Bone adaptation; Tibial compression; Aging; In vivo loading; Mouse tibia
Categories
Funding
- NIH/NIAMS [R01 AR047867, P30 AR057235]
- Washington University Musculoskeletal Research Center
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Axial compression of the mouse tibia is used to study strain-adaptive bone (re)modeling. In some studies, comparisons between mice of different ages are of interest. We characterized the tibial deformation and force-strain relationships in female C57Bl/6 mice at 5-, 12- and 22-months age. A three-gauge experimental method was used to determine the strain distribution at the mid-diaphysis, while specimen-specific finite element analysis was used to examine strain distribution along the tibial length. The peak strains in the tibial mid-diaphyseal cross-section are compressive and occur at the posterolateral apex. The magnitudes of these peak compressive strains are 1.5 to 2 times those on the opposite, antero-medial face (a site often used for strain gauge placement). For example, -10 N force applied to a 5-months old mouse engenders a peak compressive strain of -2800 mu epsilon and a tensile strain on the antero-medial face of + 1450 mu epsilon. The orientation of the neutral axis at the mid-diaphysis did not differ with age (p = 0.46), indicating a similar deformation mode in young and old tibiae. On the other hand, from 5- to 22-months there is a 25% reduction in cortical thickness and moment of inertia (p < 0.05), resulting in significantly greater tibial strain magnitudes in older mice for equivalent applied force (p < 0.05). We conclude that comparisons of tibial loading responses in young-adult and old C57Bl/6 tibiae are facilitated by similar deformation pattern across ages, but that modest adjustment of force levels is required to engender matching peak strains. (C) 2013 Elsevier Ltd. All rights reserved.
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