Journal
JOURNAL OF BIOMECHANICS
Volume 47, Issue 14, Pages 3475-3481Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2014.09.010
Keywords
Magnetic resonance imaging (MRD); Acceleration; Deformation; Strain; Traumatic brain injury (TBI)
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Funding
- Department of Defense in the Center for Neuroscience and Regenerative Medicine
- National Institutes of Health [R01-NS055951]
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In vivo measurements of human brain deformation during mild acceleration are needed to help validate computational models of traumatic brain injury and to understand the factors that govern the mechanical response of the brain. Tagged magnetic resonance imaging is a powerful, noninvasive technique to track tissue motion in vivo which has been used to quantify brain deformation in live human subjects. However, these prior studies required from 72 to 144 head rotations to generate deformation data for a single image slice, precluding its use to investigate the entire brain in a single subject. Here, a novel method is introduced that significantly reduces temporal variability in the acquisition and improves the accuracy of displacement estimates. Optimization of the acquisition parameters in a gelatin phantom and three human subjects leads to a reduction in the number of rotations from 72 to 144 to as few as 8 for a single image slice. The ability to estimate accurate, well-resolved, fields of displacement and strain in far fewer repetitions will enable comprehensive studies of acceleration-induced deformation throughout the human brain in vivo. (C) 2014 Elsevier Ltd. All rights reserved.
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