Journal
JOURNAL OF BIOMECHANICS
Volume 46, Issue 2, Pages 253-265Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2012.10.025
Keywords
Bone porosity; Permeability; Interstitial fluid flow; Lacunar-canalicular system; Vascular system
Categories
Funding
- NIH [ARRA RCI HL101151, AG034198, AR052866]
- NSF [MRI 0723027, MRI 1229449]
- Arthritis Foundation [AF229767]
Ask authors/readers for more resources
This contribution reviews recent research performed to assess the porosity and permeability of bone tissue with the objective of understanding interstitial fluid movement. Bone tissue mechanotransduction is considered to occur due to the passage of interstitial pore fluid adjacent to dendritic cell structures in the lacunar-canalicular porosity. The movement of interstitial fluid is also necessary for the nutrition of osteocytes. This review will focus on four topics related to improved assessment of bone interstitial fluid flow. First, the advantages and limitations of imaging technologies to visualize bone porosities and architecture at several length scales are summarized. Second, recent efforts to measure the vascular porosity and lacunar-canalicular microarchitecture are discussed. Third, studies associated with the measurement and estimation of the fluid pressure and permeability in the vascular and lacunar-canalicular domains are summarized. Fourth, the development of recent models to represent the interchange of fluids between the bone porosities is described. (c) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available