Journal
JOURNAL OF BIOMECHANICS
Volume 45, Issue 5, Pages 832-841Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2011.11.024
Keywords
Cardiomyocytes; Cell alignment; Bio-hybrid thin film; Constitutive model; Finite element simulation; Pre-stretch; Isometric twitch stress
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Funding
- Harvard Materials Research Science and Engineering Center under NSF [DMR-0820484, DMR-0213805]
- NIH [1 R01 HL079126]
- Harvard SEAS Academic Computing
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [820484] Funding Source: National Science Foundation
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Recent progress in tissue engineering has made it possible to build contractile bio-hybrid materials that undergo conformational changes by growing a layer of cardiac muscle on elastic polymeric membranes. Further development of such muscular thin films for building actuators and powering devices requires exploring several design parameters, which include the alignment of the cardiac myocytes and the thickness/Young's modulus of elastomeric film. To more efficiently explore these design parameters, we propose a 3-D phenomenological constitutive model, which accounts for both the passive deformation including pre-stretch and the active behavior of the cardiomyocytes. The proposed 3-D constitutive model is implemented within a finite element framework, and can be used to improve the current design of bio-hybrid thin films and help developing bio-hybrid constructs capable of complex conformational changes. (C) 2011 Elsevier Ltd. All rights reserved.
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