Journal
JOURNAL OF BIOMECHANICS
Volume 44, Issue 6, Pages 1209-1211Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2011.01.032
Keywords
Elastin; Collagen; Anisotropy; Stress; Biomechanics
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Funding
- Technical University of Denmark [55562]
- Radiometer Medical ApS.
- Danish Ministry of Science Technology and Innovation
- NIH [R01 HL086418]
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Cigarette smoking is the leading self-inflicted risk factor for cardiovascular diseases: it causes arterial stiffening with serious sequelea including atherosclerosis and abdominal aortic aneurysms. This work presents a new interpretation of arterial stiffening caused by smoking based on data published for rat pulmonary arteries. A structurally motivated four fiber family constitutive relation was used to fit the available biaxial data and associated best-fit values of material parameters were estimated using multivariate nonlinear regression. Results suggested that arterial stiffening caused by smoking was reflected by consistent increase in an elastin-associated parameter and moreover by marked increase in the collagen-associated parameters. That is, we suggest that arterial stiffening due to cigarette smoking appears to be isotropic, which may allow simpler phenomenological models to capture these effects using a single stiffening parameter similar to the approach in isotropic continuum damage mechanics. There is a pressing need, however, for more detailed histological information coupled with more complete biaxial mechanical data for a broader range of systemic arteries. (C) 2011 Elsevier Ltd. All rights reserved.
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