Journal
JOURNAL OF BIOMECHANICS
Volume 44, Issue 8, Pages 1553-1558Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2011.02.084
Keywords
Malaria; Margination; Hydrodynamic interaction; Numerical simulation
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Funding
- JSPS [19100008, 20700373]
- Global Nano-Biomedical Engineering Education and Research Network Center
- Global Enterprise for Micro-Mechanics and Molecular Medicine Laboratory at the National University of Singapore [GEM4]
- Grants-in-Aid for Scientific Research [20700373, 19100008, 23220012] Funding Source: KAKEN
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We investigated numerically the mechanism of margination of Plasmodium falciparum malaria-infected red blood cells (Pf-IRBCs) in micro-scale blood flow. Our model illustrates that continuous hydrodynamic interaction between a Pf-IRBC in the trophozoite stage (Pf-T-IRBC) and healthy red blood cells (HRBCs) results in the margination of the Pf-T-IRBC and, thus, a longer duration of contact with endothelial cells. The Pf-T-IRBC and HRBCs first form a train. The volume fraction of RBCs is then locally increased, to approximately 40%, and this value is maintained for a long period of time due to the formation of a long train in high-hematocrit conditions. Even in low-hematocrit conditions, the local volume fraction is instantaneously elevated to 40% and the Pf-T-IRBC can migrate to the wall. However, the short train formed in low-hematocrit conditions does not provide continuous interaction, and the Pf-T-IRBC moves back to the center of the channel. (C) 2011 Elsevier Ltd. All rights reserved.
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