Journal
JOURNAL OF BIOMECHANICS
Volume 42, Issue 4, Pages 550-554Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2008.10.006
Keywords
Cerebral aneurysm; Hemodynamics; Wall shear stress gradient; Temporal fluctuation; Computational fluid dynamics
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We propose a new hemodynamic index for the initiation of a cerebral aneurysm, defined by the temporal fluctuations of tension/compression forces acting on endothelial cells. We employed a patient-specific geometry of a human internal carotid artery (ICA) with an aneurysm, and reconstructed the geometry of the ICA before aneurysm formation by artificially removing the aneurysm. We calculated the proposed hemodynamic index and five other hemodynamic indices (wall shear stress (WSS) at peak systole, time-averaged WSS, time-averaged spatial WSS gradient, oscillatory shear index (OSI), and potential aneurysm formation indicator (AFI)) for the geometry before aneurysm formation using a computational fluid dynamics technique. By comparing the distribution of each index at the location of aneurysm formation, we discussed the validity of each. The results showed that only the proposed hemodynamic index had a significant correlation with the location of aneurysm formation. Our findings suggest that the proposed index may be useful as a hemodynamic index for the initiation of cerebral aneurysms. (c) 2008 Elsevier Ltd. All rights reserved.
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