Journal
JOURNAL OF BIOMECHANICS
Volume 42, Issue 2, Pages 178-182Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2008.10.038
Keywords
Cyclic tensile strain; Mechanical; Strain gradient; PDMS; 3D strain; 2D strain; Fibrin gel; Endothelial cells; Migration
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Funding
- Harvard MRSEC
- NSF Award [DMR 02-13805]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [820484] Funding Source: National Science Foundation
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The development of a multi-sample strain device and elastomeric culture wells designed to systematically assess strain effects on cell cultures is presented in this report. This device enables one to precisely conduct experimental analyses in sterile conditions while delivering cyclic uniaxial tensile strain. The input to the computer interface allows one to alter variables of frequency, duration, and amplitude of strain. The influence of strain on the migration of human umbilical vein endothelial cell (HUVEC) cultured on 2D polydimethylsiloxane (PDMS) surfaces was examined to verify the utility of this system. (C) 2008 Elsevier Ltd. All rights reserved.
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