Journal
JOURNAL OF BIOMECHANICS
Volume 41, Issue 1, Pages 47-55Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2007.07.020
Keywords
microscopic blood flows; aggregation; hemodynamics; hemorheology; lattice Boltzmann method
Categories
Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R56HL052684, R01HL018292, R01HL052684] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL018292, R01 HL052684-04, R56 HL052684, HL/52684, R01 HL052684] Funding Source: Medline
Ask authors/readers for more resources
In this paper we develop a lattice Boltzmann algorithm to simulate red blood cell (RBC) behavior in shear flows. The immersed boundary method is employed to incorporate the fluid-membrane interaction between the flow field and deformable cells. The cell membrane is treated as a neo-Hookean viscoelastic material and a Morse potential is adopted to model the intercellular interaction. Utilizing the available mechanical properties of RBCs, multiple cells have been studied in shear flows using a two-dimensional approximation. These cells aggregate and form a rouleau under the action of intercellular interaction. The equilibrium configuration is related to the interaction strength. The end cells exhibit concave shapes under weak interaction and convex shapes under strong interaction. In shear flows, such a rouleau-like aggregate will rotate or be separated, depending on the relative strengths of the intercellular interaction and hydrodynamic viscous forces. These behaviors are qualitatively similar to experimental observations and show the potential of this numerical scheme for future studies of blood flow in microvessels. (c) 2007 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available