Journal
JOURNAL OF BIOMECHANICS
Volume 41, Issue 11, Pages 2585-2588Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2008.05.018
Keywords
bone; nanoindentation; composite bounds; elastic modulus; mineral volume fraction
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Funding
- Veterinary Advisory Committee of the Horserace Betting Levy Board
- Medical Research Council (MRC) of UK
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Advances in diagnosis and treatment of some bone disorders can be made by understanding the linkage between mineral content and mechanical function. Bone is approximately half by volume a hydrated protein network, and the remainder is a biomineral analogue Of hydroxyapatite. In the current work, paired measurements of mechanical properties, using nanoindentation, and of bone mineral volume fraction. computed from quantitative back-scattered electron imaging, were made on six different types of normal and outlier bone samples. Local elastic modulus Was Plotted against mineral fraction and compared with predictions of engineering bounds for a two-phase composite material. Experimental data spanning the composite bounds showed no one-to-one relationship between mechanical stiffness and bone composition, excluding the possibility of any single, simple composites model for bone at nanometer length-scales. (C) 2008 Elsevier Ltd. All rights reserved.
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