Journal
JOURNAL OF BIOMECHANICS
Volume 41, Issue 11, Pages 2567-2570Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2008.05.027
Keywords
blood vessel; remodeling; optimal design
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Funding
- National Institute of Health-National Heart, Lung, and Blood Institute [2 R01 HL055554-11, HL84529]
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Arterial remodeling is an important process in physiology and pathophysiology. Based on in energy minimization method, Murray's law predicts the optimal inner radius. Application of Darcy's law in the wall results in an optimal outer radius. The average wall stress is computed by the Laplace's law. Using these formulas, a large porcine coronary artery in hypertension is Studied. The results reveal how wall thickness and average circumferential stress change after increasing blood pressure and volume flow rate. The theoretical predictions are in Rood qualitative agreement with experimental observations. The advantage and limitation of the current approach are discussed. (C) 2008 Published by Elsevier Ltd.
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