Journal
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
Volume 132, Issue 11, Pages -Publisher
ASME
DOI: 10.1115/1.4002551
Keywords
tissue engineering; time dependency; scaffolds mechanical properties; degradation
Categories
Funding
- Saskatchewan Health Research Foundation (SHRF)
- Natural Science and Engineering Research Council (NSERC) of Canada
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The mechanical properties of tissue engineering scaffolds play a critical role in the success of repairing damaged tissues/organs. Determining the mechanical properties has proven to be a challenging task as these properties are not constant but depend upon time as the scaffold degrades. In this study, the modeling of the time-dependent mechanical properties of a scaffold is performed based on the concept of finite element model updating. This modeling approach contains three steps: (1) development of a finite element model for the effective mechanical properties of the scaffold, (2) parametrizing the finite element model by selecting parameters associated with the scaffold microstructure and/or material properties, which vary with scaffold degradation, and (3) identifying selected parameters as functions of time based on measurements from the tests on the scaffold mechanical properties as they degrade. To validate the developed model, scaffolds were made from the biocompatible polymer polycaprolactone (PCL) mixed with hydroxylapatite (HA) nanoparticles and their mechanical properties were examined in terms of the Young modulus. Based on the bulk degradation exhibited by the PCL/HA scaffold, the molecular weight was selected for model updating. With the identified molecular weight, the finite element model developed was effective for predicting the time-dependent mechanical properties of PCL/HA scaffolds during degradation. [DOI:10.1115/1.4002551]
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