Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 25, Issue 17, Pages 1962-1972Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2014.965996
Keywords
crosslinked membranes; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC); collagen; chitosan
Funding
- National Key Technologies RD Program [2012BAI17B02]
- National Nature Science Foundation of China [51273072, 50803018, 51232002]
- Nature Science Foundation of Guangdong [2012A080203010, 2012A080800015]
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This article describes a chitosan-collagen composite membrane as corneal tissue-engineering biomaterials. The membrane was prepared by dissolving the chitosan into collagen with the weight ratio of 0, 15, 30, 45, 60, and 100%, followed by crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. Mechanical properties, contact angles, and optical transmittance were determined and compared between chitosan membrane and crosslinking composite membrane. As a result, the optical transparency and mechanical strength of the chitosan-collagen membranes were significantly better than that of the sample of chitosan. In addition, in vitro cell culture studies revealed that the collagen has no negative effect on the cell morphology, viability, and proliferation and possess good biocompatibility. Overall, the dendrimer crosslinked chitosan-collagen composite membranes showed promising properties that suggest that these might be suitable biomaterials for corneal tissue-engineering applications.
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