Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 24, Issue 14, Pages 1692-1706Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2013.792642
Keywords
polyurethane; polycaprolactone; electrospinning; endothelial cells
Funding
- Mid-career Research Program through NFR
- MEST, Republic of Korea [2009-0092808]
- National Research Foundation of Korea [2009-0092808] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, a novel hybrid polyurethane/polycaprolactone (PU/PCL) tubular scaffold was fabricated using the electrospinning process for blood vessel prosthesis applications. The detailed microstructure and material properties such as porosity, tensile and bust strength, contact angle, and biocompatibility were investigated and compared with those of monolithic PU and PCL scaffolds. The mechanical properties of the hybrid PU/PCL scaffold (tensile strength: 18MPa, pressure strength: 590mmHg) were found to be within the range needed for artificial blood vessel applications. The pore sizes of the PU/PCL scaffold ranged from 5-150um in diameter, are sufficient enough to allow nutrient diffusion across the membrane. The reduced hydrophobic property of the PU/PCL scaffold was the result of the addition of relatively less hydrophobic PU compared with monolithic PCL scaffold. The biocompatibility of the PU/PCL scaffold was evaluated through cytotoxicity testing, and morphological observation by scanning electron microscopy and confocal microscopy using cow pulmonary artery endothelial cells and fibroblast like cells (L929).
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