4.5 Article

Gelatin-Based Emulsion Gels for Diffusion-Controlled Release Applications

Journal

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 23, Issue 5, Pages 645-661

Publisher

VSP BV
DOI: 10.1163/092050611X555830

Keywords

Gelatin; emulsion gel; genipin; swelling; drug release

Funding

  1. Natural Sciences and Engineering Research Council of Canada (NSERC)
  2. Advanced Food and Materials Network (AFMNet)
  3. Indian Institute of Technology - Kharagpur

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Emulsion gels are now emerging as a new class of biomaterials for controlled-release applications. Novel food-grade emulsion gels consisting of indomethacin-loaded vegetable oil droplets dispersed within genipin-cross-linked gelatin-based hydrogels were characterized for their physical and drug-release properties. Varying the weight ratio of the aqueous and oil phases between 5:1 and 5:5 was used to modulate construct swelling and drug release. The dispersed oil droplets generally became larger, more polydispersed and aggregated with an increase in oil fraction. Cross-linking with genipin increased the puncture strength of the gels vs. their uncross-linked counterparts and was necessary to prevent breakdown. Swelling of the emulsion gels demonstrated Fickian behaviour at all gelatin: oil ratios. Indomethacin release followed Fickian diffusion at higher oil fractions only, demonstrating coupled Fickian and super-Case-11 transport at lower oil ratios (5:1, 5:2 and 5:3). Overall, the introduction of a dispersed oil phase within a hydrogel was exploited for the release of hydrophobic bioactive compounds, with tailoring of composition used to significantly alter release kinetics. (C) Koninklijke Brill NV, Leiden, 2012

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