Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 24, Issue 6, Pages 684-695Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2012.706470
Keywords
fibrinolytic surface; L605 cobaltchromium stent; poly(2-hydroxyethyl methacrylate); protein adsorption
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- National Natural Science Foundation of China [20920102035, 21174098]
- National Science Fund for Distinguished Young Scholars [21125418]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Prevention of coagulation appears not to be possible when a foreign surface is in contact with blood; the alternative concept of a clot lysing surface has therefore been suggested. In this work, a mimic of the fibrinolytic system was constructed on L605 cobaltchromium coronary stents. Lysine which, immobilized on a surface, has been shown previously to adsorb plasminogen in contact with blood was attached to the stent using poly(2-hydroxyethyl methacrylate) (poly(HEMA)) as a spacer. The lysine-poly(HEMA) modified stent was shown to have low nonspecific protein adsorption and to bind plasminogen in high quantity from plasma. Following exposure to plasma and treatment with tissue plasminogen activator, the lysine-modified stents showed clot-lysing properties in vitro while the unmodified L605 stents did not. It was shown that the modified stents retained their clot lysing properties after 24h exposure to plasma.
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