Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 22, Issue 1-3, Pages 19-40Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/092050609X12572464984331
Keywords
Chitosan; scaffold; biodegradation; protein absorption; compressive strength
Funding
- National Science Foundation of China [50603017, 50873075]
- Tianjin Municipal Science and Technology Commission, P.R. China [06YFGZGX03000]
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Chitosan, as an example of natural macromolecular biomaterials, was used to fabricate highly porous chitosan scaffolds with microtubules having a tubular orientation structure using the unidirectional freeze-drying method. The porous structure of the scaffolds was characterized via scanning electron microscopy. The factors that affect the porous structure of the scaffolds, such as the concentration of chitosan solution and addition of glutaraldehyde as cross-linking agent, have been extensively studied in order to find a facile and efficient way to control the porosity, tubular morphology and orientation of the microtubules. The properties of the chitosan scaffolds, including water absorption ability, compressive strength, protein adsorption and in vitro enzymatic biodegradation in the presence of lysozyme, were also investigated. In vitro cell-culture results showed that the chitosan scaffold was non-toxic to cartilage cells and the cells could spread and grow well on the scaffolds. (C) Koninklijke Brill NV, Leiden, 2011
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