Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 21, Issue 13, Pages 1761-1782Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/092050609X12567178204169
Keywords
Elastomer; photo-cross-linking; biodegradable; tissue engineering; wound dressing; citric acid
Funding
- American Heart Association (AHA)
- National Institute of Health/National Institute of Biomedical Imaging and Bioengineering (NIH/NIBIB) [R21EB009795]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB007271, R21EB009795] Funding Source: NIH RePORTER
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Citric-acid-derived thermally cross-linked biodegradable elastomers (CABEs) have recently received significant attention in various biomedical applications, including tissue-engineering orthopedic devices, bioimaging and implant coatings. However, citric-acid-derived photo-cross-linked biodegradable elastomers are rarely reported. Herein, we report a novel photo-cross-linked biodegradable elastomer, referred to as poly(octamethylene maleate citrate) (POMC), which preserves pendant hydroxyl and carboxylic functionalities after cross-linking for the potential conjugation of biologically active molecules. Pre-POMC is a low-molecular-mass pre-polymer with an average molecular mass between 701 and 1291 Da. POMC networks are soft and elastic with an initial modulus of 0.07 to 1.3 MPa and an elongation-at-break between 38 and 382%. FT-IR-ATR results confirmed the successful surface immobilization of type-I collagen onto POMC films, which enhanced in vitro cellular attachment and proliferation. Photo-polymerized POMC films implanted subcutaneously into Sprague-Dawley rats demonstrated minimal in vivo inflammatory responses. The development of POMC enriches the family of citric-acid-derived biodegradable elastomers and expands the available biodegradable polymers for versatile needs in biomedical applications. (C) Koninklijke Brill NV, Leiden, 2010
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