Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 21, Issue 1, Pages 37-51Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856209X410193
Keywords
Stromal-cell-derived factor-1 (SDF-1); controlled release; angiogenesis; gelatin hydrogel
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Controlled release of a chemokine, stromal-cell-derived factor-1 (SDF-1), could be achieved with gelatin hydrogels of release carrier. Gelatin was chemically derivatized to give it different electric charge and hydrophobicity. Among the derivatives, succinylated gelatin (Succ) of an anionic charge was the most suitable for preparation of the hydrogel in terms of SDF-1 release. The time profile of SDF-1 release from the hydrogel of succinylated gelatin could be controlled by changing the water content of hydrogel which could be modified by changing the conditions of hydrogel preparation. When evaluated after the subcutaneous implantation of Succ hydrogels incorporating SDF-1 or injection of SDF-1 solution, significantly stronger angiogenesis by the hydrogel was observed. The hydrogel implantation also enhanced the mRNA level of SDF-1 receptor at the site implanted. It is possible that the gelatin hydrogel enabled SDF-1 to be released locally, resulting in an enhanced angiogenesis at the site implanted. (c) Koninklijke Brill NV, Leiden, 2010
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