Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 20, Issue 3, Pages 325-339Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856209X412191
Keywords
Polyhydroxyalkanoates; PHBV; PHBHHx; PLA; mesenchymal stem cells
Funding
- Li Ka Shing Foundation
- State High Tech Project 863 [2006AA02Z242]
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As a new member of the polyhydroxyalkanoate (PHA) family, the terpolyester poly(3-hydroxybutyrateco-3- hydroxyvalerate-co-3-hydroxyhexanoate) (PHBVHHx) was evaluated for its biocompatibility for human umbilical cord Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs). More WJ-MSC adhesion and proliferation were observed on PHBVHHx film compared with films made of poly(L-lactic acid) (PLA), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx). Higher DNA synthesis by WJ-MSCs was detected on PHBVHHx film than on PLA, PHBV and PHBHHx films. PHBVHHx film had a rougher surface and more adsorption of extracellular matrix (ECM) proteins including collagen I, fibronectin and vitronectin, compared with PLA, PHBV and PHBHHx films. PHBVHHx film was also more hydrophobic than PLA and PHBV. These results demonstrated that PHBVHHx could be a promising biomaterial in medical implant applications for supporting the growth of cells, including WJ-MSCs. (c) Koninklijke Brill NV, Leiden, 2009
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