Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 19, Issue 1, Pages 131-142Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1163/156856208783227686
Keywords
PAMAM dendrimer conjugate; LHRH peptide; stability
Funding
- OFFICE OF THE DIRECTOR, NCI [N01CO097111] Funding Source: NIH RePORTER
- NCI NIH HHS [N0I-CO-97111] Funding Source: Medline
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Cancer targeting is crucial for cancer detection, therapy and targeted drug delivery. A dendrimer-peptide conjugate has been synthesized based on poly(amidoamine) dendrimer generation 5 (PAMAM G5) as a platform and a luteinizing hormone-releasing hormone (LHRH) peptide as a targeting moiety. The synthesized conjugate was fully characterized using nuclear magnetic resonance (NMR), UV-Vis spectrometry, reverse-phase high-performance liquid chromatography (RP-HPLC) and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry. Further stability experiments showed that the synthesized conjugate was stable after 72-h incubation in phosphate-buffered saline (PBS) buffer (pH 7.4) at 37 degrees C. The synthesized conjugate may find applications in biomedical targeting, gene delivery and imaging.
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