Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 29, Issue 4, Pages 566-581Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328214537694
Keywords
Embolic microspheres; dissolution; genotoxicity; ion release
Funding
- Canadian Institutes of Health Research (CIHR) [276947]
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Embolization of vascular tumors is an important tool in minimally invasive surgical intervention. Radiopaque, non-degradable, and non-deformable spherical zinc-silicate glass particles were produced in a range of 45-500m. Three size ranges (45-150, 150-300, and 300-500m) were used in the current study. The glass microspheres were eluted in polar (saline solution) and non-polar (dimethyl sulfoxide) medium, and ion release profiles were recorded using inductively coupled plasma atomic emission spectroscopy. Approximately 80% of Gaussian distribution was achieved by simple sieving. The ions released from the microspheres were dependent upon surface area to volume ratio as well as the nature of elution media. Greater ions were released from smaller particles (45-150m) having largest surface area in polar medium. For the genotoxicity bacterial mutation Ames assay, the concentrations of all the ions were well below their therapeutic concentration reported in the literature. No mutagenic effect was observed in the bacterial mutation Ames test. Hence, it can be concluded that the glass microspheres produced herein are non-mutagenic further supporting the materials potential as a suitable embolic agent.
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