Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 28, Issue 5, Pages 676-687Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328212472216
Keywords
Arterial prosthesis; poly(ethylene terephthalate); silk; small diameter; mechanical properties; cytocompatibility
Funding
- NSFC [51003014, 31100682]
- RFDP [20100075110001]
- Fundamental Research Funds of Central Universities [12D10147, 11D10118]
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The development of a small diameter (5mm) arterial prosthesis requires the appropriate selection of materials, structure and fabrication method so as to provide adequate mechanical properties, superior biocompatibility and precise control over the diameter. In this study, 100% polyester, 100% silk fibroin and a combination of both yarns were woven into seamless tubular prototype prostheses with different basic weaves. After degumming/scouring they met a target inner diameter of 3.9 +/- 0.3mm which demonstrates that weaving is a precise way to manufacture small caliber arterial prostheses. In conclusion, the bicomponent polyester/silk woven samples had superior mechanical properties and improved cytocompatibility compared to commercial ePTFE devices.
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