Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 28, Issue 1, Pages 49-61Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328212437065
Keywords
Nanorods; hydroxyapatite; CTAB; cell adhesion; cell affinity
Funding
- Bridging-The Gap Erasmus Mundus Project
- Provincia of Trento Smartbone project
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Synthetic hydroxyapatite nanorods are excellent candidates for bone tissue engineering applications. In this study, hydroxyapatite nanorods resembling bone minerals were produced by using soft-template method with cetyltrimethylammonium bromide. Composite hydroxyapatite/poly(D, L) lactic acid films were prepared to evaluate the prepared hydroxyapatite nanorods in terms of cell affinity. Preliminary in vitro experiments showed that aspect ratio and film surface roughness play a vital role in controlling adhesion and proliferation of human osteoblast cell line MG 63. The hydroxyapatite nanorods with aspect ratios in the range of 5.94-7 were found to possess distinctive properties, with the corresponding hydroxyapatite/poly(D, L) lactic acid films promoting cellular confluence and a fast formation of collagen fibers as early as after 7 days of culture.
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