Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 24, Issue 7, Pages 657-672Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328209340334
Keywords
calcium titanate; hydroxyapatite; coating; titanium; osteoblasts
Funding
- Japan Society for the Promotion of Science for Young Scientists [1945179, 20592200]
- Grants-in-Aid for Scientific Research [20592200] Funding Source: KAKEN
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Titanium and hydroxyapatite (HA) are widely used as biomaterials for dental and medical applications. HA-coated titanium implants have excellent biocompatibility and mechanical properties. However, the adherence of HA film formed on titanium substrate is weak because of the lack of chemical interaction between HA and titanium. A solution to this problem is to form an intermediate film on titanium substrate, which provide excellent adherence to both titanium substrate and HA. We developed a novel biomaterial called calcium titanate-amorphous carbon (CaTiO3-aC) coating prepared by modified thermal decomposition-method. The purpose of this study was to evaluate the effect of CaTiO3-aC and HA coating (positive control), and Ti (negative control) on osteoblastic (MT3T3-E1) cell responses. An increased cellular proliferation was observed in CaTiO3-aC coating compared to HA coating. The maximum expressions of ALP activity, Col I and ALP mRNA were higher and achieved in shorter period of time in CaTiO3-aC coating compared to others. These results demonstrated that CaTiO3-aC promoted better cell attachment, cellular proliferation, and osteoblastic differentiation compared with HA. In conclusion, we suggested that CaTiO3-aC could be considered as an important candidate as a coating material.
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