TRANSITION OF ORDERED WAVES IN NEURONAL NETWORK INDUCED BY DIFFUSIVE POISONING OF ION CHANNELS

Normal physiological activities are often affected by some drugs, and some ion channels are blocked due to the katogene of drugs. This paper investigates the propagation of ordered waves in neuronal networks induced by diffusive poisoning, where the process is measured by increasing the number of neurons in the poisoned area of the networks. A coefficient of poisoning K is defined to measure the time units from one poisoned site to the adjacent site, a smaller K means that more neurons are poisoned in a certain period (a higher poisoning speed). A statistical factor of synchronization R in the two-dimensional array is defined to detect the transition of spiral waves induced by ion channel blocking. It is confirmed that the evolution of the spiral waves depends on the coefficient of poisoning K and number of poisoned neurons. Furthermore, breakup of the spirals is observed when weak channel noise is considered. Finally, the formation of the spiral wave induced by blocking the target wave with line defects is briefly discussed.