Journal
JOURNAL OF BIOLOGICAL PHYSICS
Volume 35, Issue 4, Pages 317-336Publisher
SPRINGER
DOI: 10.1007/s10867-009-9157-9
Keywords
Astrocytes; Neurological diseases; Neurodegeneration; Glial cells
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Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte homeostasis, cell signaling, inflammation, and synapse modulation. Astrocytes are, in fact, part of a bidirectional crosstalk with neurons. Moreover, increasing evidence is stressing the emerging role of astrocyte dysfunction in the pathophysiology of neurological disorders, including neurodegenerative disease, stroke, epilepsy, migraine, and neuroinflammatory diseases.
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