Journal
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
Volume 14, Issue 6, Pages 935-945Publisher
SPRINGER
DOI: 10.1007/s00775-009-0506-8
Keywords
Arene; Carbonic anhydrase; Organometallic; Ruthenium; Sulfonamide
Funding
- Australian Research Council [DP0877554]
- Queensland Institute of Medical Research
- Australian Research Council [DP0877554] Funding Source: Australian Research Council
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Cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide sandwich complexes have been synthesized and screened for enzymatic inhibition of the physiologically dominant carbonic anhydrase (CA) isozymes: human CA I and II, mitochondrial isozymes VA and VB, and the cancer-associated isozyme IX. The complexes demonstrated weaker binding to CAs compared with typical aromatic sulfonamides, inhibiting the enzyme at high nanomolar concentrations. An in vitro cytotoxic evaluation of the complexes was also undertaken against a range of tumorigenic cell lines and a healthy human cell line. Complexes inhibited the growth of cancerous cells at low micromolar concentrations while expressing lower levels of toxicity towards the normal human cell line. Factors influencing the synthesis, cytotoxicity, and enzyme affinity for this series of organometallic complexes are discussed.
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