Related references
Note: Only part of the references are listed.Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
Thomas Eicher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Ryosuke Nakashima et al.
NATURE (2011)
Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coli
Siew Ping Lim et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2010)
Roll: a new algorithm for the detection of protein pockets and cavities with a rolling probe sphere
Jian Yu et al.
BIOINFORMATICS (2010)
Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1
Daniel A. P. Gutmann et al.
TRENDS IN BIOCHEMICAL SCIENCES (2010)
Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli
Keiji Nagano et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Multidrug efflux transporter, AcrB - the pumping mechanism
Satoshi Murakami
CURRENT OPINION IN STRUCTURAL BIOLOGY (2008)
Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB
Juergen A. Bohnert et al.
JOURNAL OF BACTERIOLOGY (2008)
The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2)
L. J. A. Hardwick et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors
Gaby Sennhauser et al.
PLOS BIOLOGY (2007)
Crystal structures of a multidrug transporter reveal a functionally rotating mechanism
Satoshi Murakami et al.
NATURE (2006)
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism
Markus A. Seeger et al.
SCIENCE (2006)
Purification of breast cancer resistance protein ABCG2 and role of arginine-482
A. Pozza et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding
Karin F. K. Ejendal et al.
PROTEIN SCIENCE (2006)
Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa
JK Middlemiss et al.
JOURNAL OF BACTERIOLOGY (2004)
Extramembrane central pore of multidrug exporter AcrB in Escherichia coli plays an important role in drug transport
S Murakami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants
M Miwa et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Roles of TolC-dependent multidrug transporters of Escherichia coli in resistance to β-lactams
K Nishino et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)
Multidrug-exporting secondary transporters
S Murakami et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2003)
Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli
H Hirakawa et al.
JOURNAL OF BACTERIOLOGY (2003)
An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space
S Eda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Chimeric analysis of the multicomponent multidrug efflux transporters from gram-negative bacteria
EB Tikhonova et al.
JOURNAL OF BACTERIOLOGY (2002)
Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominately by two large periplasmic loops
CA Elkins et al.
JOURNAL OF BACTERIOLOGY (2002)
On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps:: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition
WM Mao et al.
MOLECULAR MICROBIOLOGY (2002)
Crystal structure of bacterial multidrug efflux transporter AcrB
S Murakami et al.
NATURE (2002)
Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: Our worst nightmare?
DM Livermore
CLINICAL INFECTIOUS DISEASES (2002)
Structural mechanisms of QacR induction and multidrug recognition
MA Schumacher et al.
SCIENCE (2001)
Analysis of a complete library of putative drug transporter genes in Escherichia coli
K Nishino et al.
JOURNAL OF BACTERIOLOGY (2001)
Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes
MC Sulavik et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2001)
A set of temperature sensitive-replication/-segregation and temperature resistant plasmid vectors with different copy numbers and in an isogenic background (chloramphenicol, kanamycin, lacZ, repA, par, polA)
T Hashimoto-Gotoh et al.
GENE (2000)