Related references
Note: Only part of the references are listed.Allosteric inhibition of HIV-1 integrase activity
Alan Engelman et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2013)
The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
Lei Feng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells
Mini Balakrishnan et al.
PLOS ONE (2013)
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
Kellie A. Jurado et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
Belete Ayele Desimmie et al.
RETROVIROLOGY (2013)
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage
Erwann Le Rouzic et al.
RETROVIROLOGY (2013)
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy
Frauke Christ et al.
VIROLOGY (2013)
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER
Oliver S. Smart et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2012)
Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization
Frauke Christ et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Discovery of small molecule HIV-1 integrase dimerization inhibitors
Cristina Tintori et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
3′-Processing and strand transfer catalysed by retroviral integrase in crystallo
Stephen Hare et al.
EMBO JOURNAL (2012)
New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action
Manuel Tsiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
Jacques J. Kessl et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
Thomas S. Peat et al.
PLOS ONE (2012)
Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration
Zhiqi Yin et al.
PROTEIN SCIENCE (2012)
HIV-1 Antiretroviral Drug Therapy
Eric J. Arts et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
HIV DNA Integration
Robert Craigie et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Development of an AlphaScreen-Based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors
Jonas Demeulemeester et al.
JOURNAL OF BIOMOLECULAR SCREENING (2012)
HIV type-1 drug resistance in treatment-naive patients monitored using minority species assays: a systematic review and meta-analysis
Andrew J. Buckton et al.
ANTIVIRAL THERAPY (2011)
Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)
Stephen Hare et al.
MOLECULAR PHARMACOLOGY (2011)
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering
Jelle Hendrix et al.
NUCLEIC ACIDS RESEARCH (2011)
Features and development of Coot
P. Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Modification of Integration Site Preferences of an HIV-1-Based Vector by Expression of a Novel Synthetic Protein
Robert M. Silvers et al.
HUMAN GENE THERAPY (2010)
Structural Properties of HIV Integrase.Lens Epithelium-derived Growth Factor Oligomers
Kushol Gupta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
LEDGF Hybrids Efficiently Retarget Lentiviral Integration Into Heterochromatin
Rik Gijsbers et al.
MOLECULAR THERAPY (2010)
Retroviral intasome assembly and inhibition of DNA strand transfer
Stephen Hare et al.
NATURE (2010)
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
Frauke Christ et al.
NATURE CHEMICAL BIOLOGY (2010)
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration
Andrea L. Ferris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance
Stephen Hare et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Methods for integration site distribution analyses in animal cell genomes
Angela Ciuffi et al.
METHODS (2009)
Catalytically-active complex of HIV-1 integrase with a viral DNA substrate binds anti-integrase drugs
Akram Alian et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
Stephen Hare et al.
PLOS PATHOGENS (2009)
Discovery of Raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
Vincenzo Summa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Screening for antiviral inhibitors of the HIV integrase -: LEDGF/p75 interaction using the AlphaScreen™ luminescent proximity assay
Yan Hou et al.
JOURNAL OF BIOMOLECULAR SCREENING (2008)
Role of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting
Heather M. Marshall et al.
PLOS ONE (2007)
Size and shape of detergent micelles determined by small-angle x-ray scattering
Jan Lipfert et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2007)
HIV integration site selection: Analysis by massively parallel pyrosequencing reveals association with epigenetic modifications
Gary P. Wang et al.
GENOME RESEARCH (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
Ming-Chieh Shun et al.
GENES & DEVELOPMENT (2007)
Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration
Krishan K. Pandey et al.
JOURNAL OF VIROLOGY (2007)
Selection of target sites for mobile DNA integration in the human genome
Charles Berry et al.
PLOS COMPUTATIONAL BIOLOGY (2006)
Modulating target site selection during human immunodeficiency virus DNA integration in vitro with an engineered tethering factor
Angela Ciuffi et al.
HUMAN GENE THERAPY (2006)
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
F Turlure et al.
NUCLEIC ACIDS RESEARCH (2006)
A role for LEDGF/p75 in targeting HIV DNA integration
A Ciuffi et al.
NATURE MEDICINE (2005)
Effect of macromolecular crowding agents on human immunodeficiency virus type 1 capsid protein assembly in vitro
M del Alamo et al.
JOURNAL OF VIROLOGY (2005)
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
P Cherepanov et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2005)
Three-dimensional structure of HIV-1 virus-like particles by electron cryotomography
J Benjamin et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
A colorimetric determination for glycosidic and bile salt-based detergents: applications in membrane protein research
A Urbani et al.
ANALYTICAL BIOCHEMISTRY (2005)
Sedimentation equilibrium analysis of protein interactions with global implicit mass conservation constraints and systematic noise decomposition
J Vistica et al.
ANALYTICAL BIOCHEMISTRY (2004)
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes
M Llano et al.
JOURNAL OF VIROLOGY (2004)
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
RS Mitchell et al.
PLOS BIOLOGY (2004)
The stoichiometry of Gag protein in HIV-1
JAG Briggs et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
P Cherepanov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells
G Maertens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
P Cherepanov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Disulfide-linked integrase oligomers involving C280 residues are formed in vitro and in vivo but are not essential for human immunodeficiency virus replication
J Bischerour et al.
JOURNAL OF VIROLOGY (2003)
HIV-1 integration in the human genome favors active genes and local hotspots
ARW Schröder et al.
CELL (2002)
Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain
V Molteni et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2001)
Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy
E Deprez et al.
BIOCHEMISTRY (2000)
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
JCH Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and Lamm equation modeling
P Schuck
BIOPHYSICAL JOURNAL (2000)