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Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions

Journal

JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 7, Pages 3980-3986

Publisher

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R114.623793

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Funding

  1. Robert A. Welch Foundation [A-0034]
  2. National Institutes of Health [DK44083]

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In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F-420, and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.

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