Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 14, Pages 9488-9492Publisher
ELSEVIER
DOI: 10.1074/jbc.R113.538090
Keywords
ATPases; Bacterial Protein Kinases; Prokaryotic Protein Kinases; Ribosomal RNA Processing; Ribosome Assembly; Serine; Threonine Protein Kinase; RIO Kinase; Archaeal Protein Kinases
Categories
Funding
- National Science Foundation [MCB0953493]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0953493] Funding Source: National Science Foundation
Ask authors/readers for more resources
The RIO kinases existed before the split between Archaea and Eubacteria and are essential in eukaryotes. Although much has been elucidated in the past few years regarding the function of these proteins in eukaryotes, questions remain about their role in prokaryotes. Comparison of structure and sequence suggests that the ancient RIO kinases may have similar functional properties in prokaryotes as they do in eukaryotes. The conservation of charge distribution, functional residues, and overall structure supports a role for these proteins in ribosome interactions, as is their purpose in eukaryotes. However, a lack of study in this area has left little direct evidence in support of this function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available